apoquel dosage for horses apoquel dosage for horses

Apoquel is a prescription medication used to treat itching and inflammation in dogs. In more severe cases, Apoquel can be given twice per day. 25. Treatment will probably need to repeated somewhere between 1 and 6 weeks after the initial treatment course. EHV Quarantine Released at Turf Paradise Racetrack, Six Simple Spring Safeguards for Senior Horses, Evaluating the Suspensory Ligament in Cutting Horses, Regular Dental Care Important in Horses Worldwide, Investigating Equine Cases of Toxicant Exposure, Podotrochlosis: Navicular is No Longer the End of the Road for Horses. Unlike steroids, the drug has minimal impact on the immune system. Topical suspension administered in the ear. Several reports of successful use of oclacitinib to treat other diseases have been published.22-29 They include several cases of immune-mediated vascular diseases: idiopathic ear tip vasculitis in 4 dogs26 and ischemic dermatopathy in 6 dogs.28,29 In these reports, other classic medications had failed to control the disease until oclacitinib was added. Now divide the 10,000 mg by the 500 mg in the concentration. 23. Rarely, dogs on Apoquel develop new skin masses; however, a long-term study found no association between Apoquel and the development of malignant cancer. In the first 2 randomized, double-blinded, placebo-controlled clinical trials, it was shown that oclacitinib, given at a dose of 0.4 to 0.6 mg/kg q12h, induced a rapid reduction in pruritus and treatment success in 62.3% to 67% of treated cases within 7 to 14 days.7,8 Treatment success was based on reductions from baseline of at least 2 cm on the owner-assessed visual analog scale and at least 50% on the clinicians Canine Atopic Dermatitis Extent and Severity Index (CADESI-02). This medication may be a very good option for minis, since the costs will be much lower. The downside is that it can cause laminitis and can suppress their immune system. J Vet Pharmacol Ther 2014;37(4):317-324. That something could very well be allergy-induced asthma. However, a small subcategory of asthmatic horses suffer from pasture-associated equine asthma. I paid $250 for 100 pills (thats 20 5-pill doses). A horse can hypothetically be allergic to anything he touches, inhales, ingests, or has applied to or injected into his body. 15. This study showed that pruritus was improved in only 42% of the study population; thus, use of oclacitinib in cats did not seem to be as effective as in dogs. A blinded, randomized clinical trial comparing the efficacy and safety of oclacitinib and ciclosporin for the control of atopic dermatitis in client-owned dogs. Ordering patient medications is easy. Schindler C, Levy DE, Decker T. JAK-STAT signaling: from interferons to cytokines. Learn how allergies happen, how they affect your horses body, and how to avoid or treat them. Thereafter the dose should be reduced to once daily for maintenance. 13. 6. One of the things the trials found on using apoquel with horses is that they need a relatively small dose. I have noticed that in general she is more comfortable on cooler days. Once you have the horse's symptoms under control, you can try re-introducing hay. In the past 5 years, however, oclacitinib (Apoquel; zoetisus.com), a Janus kinase (JAK) inhibitor, has become another important drug in the management of allergic pruritus. My mare started on 5 pills every day and then we were able to move her down to 5 pills every other day. Nobody wants to be itchy and constantly scratching. The mare luckily didnt have a lot of food allergies and eliminating flax wasnt a big deal. Gonzales AJ, Bowman JW, Fici GJ, et al. Cochet Faivre N, Degorce-Rubiales F. Clinical eosinophilic popular dermatitis associated with histological eosinophilic granuloma rapidly responsive to oclacitinib in an adult Labrador retriever. After completing a doctorate thesis and a rotating internship at the University of Zurich, Switzerland, he moved to the United States, where he completed a 3-year veterinary dermatology residency at the University of Georgia in 2004. Hay replacement consists of any of the following: a complete pelleted diet, soaked alfalfa cubes, hay pellets, or possibly a bagged forage product like Chaffhaye. Apoquel Overdose Information Dogs that received overdoses in safety studies had side effects that included one or more of the following: vomiting, diarrhea, cysts between the toes, skin inflammation, papilloma's (warts), pneumonia, enlarged lymph nodes, and decreased blood cell production. Loft K, Simon B. With an online account, access our extensive formulary or over 40,000 unique items - 24 hours a day, 7 days a week. has been administered by veterinarians to help horses of . Banovic F, Tarigo J, Gordon H, et al. Apoquel. The powerful network of cells and antibodies known as the immune system can recognize dangerous invaders and disarm them before they hurt the host. This regimen may work better because oclacitinib has a short half-life of 4 hours. Oclacitinib can be given without food and may be discontinued without tapering. 3 Can be used for long-term maintenance or short-term therapy in dogs 12 months of age . Like other medications in its class, it may also be used off . Six adult horses with a mean weight of 528 kg were . . A follow-up study assessed the long-term safety, efficacy, and quality of life of oclacitinib-treated dogs. Licorice Roo t (Glycyrrhiza glabra) This sweet and soothing herb has been used medicinally for over 3,000 years. This study showed that pruritus was improved in only 42% of the study population; thus, use of oclacitinib in cats did not seem to be as effective as in dogs.17 A follow-up study was conducted with a higher dose (0.7 to 1.2 mg/kg) and a longer induction period (28 days). Her allergies have reared their ugly heads again - no jowl pyoderma, but ears itching. Designed by Elegant Themes | Powered by WordPress, You need to be logged in to fill out this form. Some dogs exhibit increased pruritus when the dosage is reduced to once daily. Do not use Apoquel in dogs less than 12 months of age or those with serious infections. Apoquel. The dose of APOQUEL (oclacitinib maleate) tablets is 0.18 to 0.27 mg oclacitinib/lb (0.4 to 0.6 mg oclacitinib/kg) body weight, administered orally, twice daily for up . Im not dealing with food allergies but both the company and the vet did not recommend allergy shots for my mare. However, the study showed that cyclosporine caused a 3-fold higher risk for developing gastrointestinal side effects (vomiting and diarrhea) compared with oclacitinib.12, Despite its delayed effects, cyclosporine is still a popular drug to treat canine atopic dermatitis because in some cases it can be dosed every other day or even every third day after initial daily treatment. This site is for US animal healthcare professionals. The dose of APOQUEL tablets is 0.4 mg/kg to 0.6 mg oclacitinib/kg body weight, administered orally, twice daily for up to 14 days, and then administered once daily for maintenance therapy. Vet Dermatol 2016;27(Suppl 1):84 (abstract). Vercelli A, Cornegliani L. Use of oclacitinib in treatment of canine idiopathic ear tip vasculitis. If the horse is allergic to any of them, his immune system elicits a response, and a hive forms at the injection site. Administer it orally in the mouth of the or mix it in the dog food. We can let your veterinarian know that you are interested in our compounded Dexamethasone. 17. Preventing bites is key, because itching-inflicted injury to hair follicles and skin can take months to heal. The purpose of Apoquel 16mg Tablets for dogs is to alleviate itching related to allergic dermatitis and address the signs of atopic dermatitis. After that it would be about $250 every 6 weeks or so if I cant further reduce time between pills. Trials showed that spreading out dosing was more successful than lowering. Many allergens can cause skin reactions. Since some horses have both "types" of asthma, you may need to try a stall without bedding, or experiment with different types of bedding. One of my horses was tested at New Bolton (he has since passed away) and I was told that a serum wasnt possible or effective for most of his food-bourne allergies. 19. These animals require the opposite regimen. Sometimes it goes overboard and reacts in the face of a generally harmless substancewhich the body begins to recognize as an allergenand an allergic reaction occurs. Equine Asthma- yep, that's the new name for "heaves," "RAO," "COPD" or whatever else we've called it over the years! Several of their drugs are eligible. Little PR, King VL, Davis KR, et al. Apoquel Oclacitinib Used for Pet Meds MORE expand_more savings GoodRx lowest price $75.90 (Save -22%) local_offer Avg retail price $62.49 medication Availability Brand only Get 20% off your first order with code GOODRX20 Shop Apoquel at America's #1 Pet Pharmacy for the best pet prescription medications online! Pet owners should visit ZoetisPetcare.com for product info, rewards and support. 26. My Docs are among the first in the country to use this drug on itchy and wheezy horses. J Vet Pharmacol Ther 2014;37(3):279-285. If the patient remains stable and other controlling measures-such as allergen avoidance, allergen immunotherapy, and preventive topical therapyhave been implemented, the use of oclacitinib can be limited to flare control.16, Although oclacitinib is licensed for use in dogs, it has been reported to be effective to treat pruritus in allergic diseases in other species, including cats.17-20 shutterstock.com/Thrithot, Although oclacitinib is licensed for use in dogs, it has been reported to be effective to treat pruritus in allergic diseases in other species, including cats.17-20. Many allergic reactions are evident as a mild case of transient hives. This gives you the total number of milligrams for the dose for your horse. Long-term compassionate use of oclacitinib in dogs with atopic and allergic skin disease: safety, efficacy and quality of life. Dosage Chart Currently, White is part of a team evaluating the possibility of delivering allergy shots in the form of a juice squirted under the horses tongue. But you're making a deal with the devil when you use these . Oclacitinib (APOQUEL) is a novel Janus kinase inhibitor with activity against cytokines involved in allergy. Her lifelong love of horses motivated her to adopt her college care horse, Claire, upon graduation. Do not use in breeding, pregnant, or lactating dogs. Find out more. But Im not sure how much the long term cost will be yet. Food allergies in particular you cant always do the serum for. If your horse worsens when hay is re-introduced, you'll need to consider a permanent change to one of the other options! When working with a liquid: Multiply your horse's weight in pounds times the dose rate in milligrams per pound. Dawn M. Cleaver, DVM Associate Director, Regulatory Affairs The dosages of oclacitinib of 1 mg/kg and 2 mg/kg were chosen because the dosages used for dogs (0.4-0.6 mg/kg) were not shown to be very effective in cats [ 18 ], and the higher dosage range of 0.8-1.3 appeared to be more effective in allergic cats [ 22 ]. Oclacitinib is available in 3 different tablet sizes: 3.6, 5.4, and 16 mg. She reports choosing Apoquel over corticosteroids in several of her allergic patients that are also at risk for developing laminitis. Option 4 is an oral tablet called Apoquel. In a 2019 study Radwanski et al. The second option is serum (blood) testing. Gadeyne et al compared prednisolone and oclacitinib at recommended doses and found that both drugs resulted in similar rapid effects with regard to pruritus and dermatitis reduction.11 Little et al compared oclacitinib to cyclosporine. Your Price: $2.20. Apoquel Dosing Chart For Dogs This product came to the market in the US in Fall 2020. APOQUEL may be administered with or without food. Gonzales AJ, Bowman JW, Fici GJ, et al. Its expensive, but its working. The pharmacokinetics of oclacitinib maleate, a Janus kinase inhibitor, in the dog. She has been allergy tested! If the patient remains stable and other controlling measures-such as allergen avoidance, allergen immunotherapy, and preventive topical therapyhave been implemented, the use of oclacitinib can be limited to flare control. Remove all nonessential supplements and topical solutions from your horses diet and routine. Also. This would be treatment with a systemic steroid (usually dexamethasone or prednisolone). Speak to yourveterinarian in an emergency. Vet Dermatol 2014;25(6):512-518. Helpful steps you can take include providing full-body fly apparel, applying fly spray liberally, avoiding turnout at dusk and dawn, and using fans in stalls to disrupt insect flying patterns. Atopic dermatitis is often a complex disease that requires a multifaceted approach. Gadeyne et al compared prednisolone and oclacitinib at recommended doses and found that both drugs resulted in similar rapid effects with regard to pruritus and dermatitis reduction. 20. I draw up a little calendar for them each month to help keep track. Six adult horses with a mean weight of 528 kg were administered a single dose of 0.5 mg/kg oclacitinib maleate. Because many respiratory allergies come from the dust in hay and bedding, veterinarians generally recommend maximizing fresh-air time through turnout. This treatment is typically effective, but the steroid is still absorbed into the body, which can result in laminitis risk, similar to Option 1. Before your vet administers immunotherapy, though, you must identify your horses respiratory and skin allergies. on various factors. This is totally random but figured Id mention it since I had no idea till I saw someone mention itZoetis has a rewards program and Apoquel is one of the drugs on it. Saridomichelakis MN, Olivry T. An update on the treatment of canine atopic dermatitis. Use of them does not imply any affiliation with or endorsement by them. Its an easy and cost-free strategy you can do yourself. Vet Dermatol 2015;26(3):171-179, e35. Assuming you cannot contact your vet: For hives or possible allergic airway disease (heaves), for a 1000 lb horse, give 5-10 tabs of 25mg diphenydramine crushed up and mixed in water and dosed in a syringe orally (by mouth). Vet Dermatol 2015;26:297 (abstract). Allergies can develop at any time, in any horse, and for virtually any reason. Such an immune response is essential for survival; it protects against all sorts of pathogens, from bacteria and viruses to fungi and parasites. Unlike steroids, the drug has minimal impact on the immune system. However, these studies have shown that oclacitinib can be a good alternative therapy to treat feline pruritus, especially for patients that do not respond to other treatments or do not tolerate steroids. Shes on 5 pills once a day for 7 days, after that we will drop to every other day, and then see how far we can space it out. In this study, 70% of the study population receiving oclacitinib showed improvement in pruritus compared with 75% in a group receiving methylprednisolone.18 Based on this study, a higher dose with a longer induction period seems to be the key to successfully treating feline pruritus with oclacitinib. After remission, some dogs were well controlled with a tapered dose of oclacitinib (0.2 to 0.5 mg/kg q24h), but some needed a higher dose (0.6 to 0.7 mg/kg q12h) to avoid relapse.28,29 The exact mechanisms of oclacitinib in these diseases are unknown; however, the need for daily administration of oclacitinib indefinitely to control the disease suggests that oclacitinib plays a role in controlling the disease. There is a new drug available to help allergic horses: Apoquel. Avoid storing hay in the same barn as sensitive horses, since hay particles and spores can be irritating, even from a distance and even if they are not visible in the air. So lets review why allergies happen, how they affect your horses body, and how to treat themor, better yet, how to avoid them altogether. While easy to perform, Fultz says its not always accurate at predicting the exact allergens. Pasture-associated equine asthma is most prevalent during the summer in the southeastern U.S. but has been reported worldwide. For the first two weeks, this is to be given twice per day, and then once per day after the first two weeks for maintenance. With a prescription number, easily refill prescriptions and enroll in the AutoRefill Program. There are 4 JAK families in mammals: JAK1, JAK2, JAK3, and TYK2. Oclacitinib preferably inhibits JAK1 and, to a lesser degree, JAK3, resulting in decreased activity of JAK1-dependent cytokines involved in allergy and inflammation (IL-2, IL-4, IL-6, and IL-13) as well as pruritus (IL-31). Really? All rights reserved. (https://www.zoetispetcare.com) I get $9 back for every 30 pills I order, it goes onto a Mastercard debit card that can only be used at a vets office but I spend plenty of money there. Although no studies of pharmacokinetics in cats have been published, oclacitinib is well tolerated and seems to be safe when used in cats at 1 or 2 mg/kg q12h for 28 days.21 Further studies are needed to investigate adverse effects associated with long-term use in cats. Loft K, Simon B. Skip to Article Content; Skip to Article Information; Search within. Comparing Apoquel and Cytopoint. Use of oclacitinib (Apoquel; Zoetis) for treatment of cutaneous mastocytosis in a cat. So new drugs such Atopica and Apoquel are prescribed routinely, to help dog owners find a quick fix for dog allergies. Allergies primarily affect the immune, respiratory, and integumentary (skin) systems and, if unmanaged, can seriously impact an animals performance and well-being. The most common side effect is lethargy, dry mouth, and urinary retention. The drug targets pro-inflammatory proteins, called cytokines, responsible for itching and inflammation, relieving signs of skin allergies. Apoquel is typically administered in tablet form at 0.4-0.6mg per kilo of body weight, or 0.18-0.27mg per pound of body weight, every 12 hours or twice a day. 6. Before your vet administers immunotherapy, though, you must identify your horses respiratory and skin allergies. Not really cheap any way you shake it, but considering that she was on zyretc, dex, smarthbreathe ultra, respi-free previously. 11. Cosgrove SB, Wren JA, Cleaver DM, et al. . Pre-slaughter withdrawal time is 14 days following the last dose. The dosage for dogs 10-14.9 lbs is of a 5.4 mg tablet twice daily. So what else can we do for our Equine Asthma patients? Apoquel should not be used in breeding, pregnant, or lactating dogs. ACVIM, a Florida-based large animal internal medicine specialist with an interest in respiratory disease. Alternatively, your veterinarian may be able to show you some techniques. The Janus kinases (Jaks). Fortunately, these side effects are relatively uncommon. Both can be very serious. In fact, in our recent study evaluating almost 400 potential allergens, latex proteins were the most significant allergens for diagnosing severe equine asthma..